Correlation of the cd36 rs1761667 Polymorphism and Lifestyle Factors with Fatty Acid Perception Threshold

Dionysius Subali; Elena Soegiarto; Ardy Lizuardi; Rendy Dijaya; Felicia Kartawidjajaputra; Lina Antono; Richie Delano

doi:10.56303/jhnresearch.v5i1.658

Authors

Dionysius Subali Department of Biotechnology, Faculty of Bioscience, Technology, and Innovation, Atma Jaya Catholic University of Indonesia, Tangerang, Indonesia
Elena Soegiarto Department of Food Technology, Faculty of Bioscience, Technology, and Innovation, Atma Jaya Catholic University of Indonesia, Tangerang, Indonesia
Ardy Lizuardi Nutrifood Research Center, PT. Nutrifood Indonesia, Jakarta, Indonesia
Rendy Dijaya Nutrifood Research Center, PT. Nutrifood Indonesia, Jakarta, Indonesia
Felicia Kartawidjajaputra Nutrifood Research Center, PT. Nutrifood Indonesia, Jakarta, Indonesia
Lina Antono Nutrifood Research Center, PT. Nutrifood Indonesia, Jakarta, Indonesia
Richie Delano Department of Biotechnology, Faculty of Bioscience, Technology, and Innovation, Atma Jaya Catholic University of Indonesia, Tangerang, Indonesia

Keywords:

cd36, fatty acid perception threshold, lifestyle, obesity, taste sensitivity

Abstract

Genetic variations, such as in the CD36 gene (rs1761667), may influence fat perception and dietary patterns, contributing to obesity. This cross-sectional study involved 87 office workers who underwent genotyping for cd36 rs1761667, sensory testing for oleic acid perception threshold, and assessments of body composition, physical activity, and dietary intake. No direct association was found between the cd36 rs1761667 genotype and the fatty acid perception threshold (p > 0.05). However, stratified analyses revealed that men carrying the A allele (GA/AA, n=23) had a higher body fat percentage compared to those with the GG genotype (n=11). In women, GA/AA carriers consumed more protein, while GG carriers derived a higher proportion of energy from carbohydrates. Among overweight individuals, GG carriers reported higher carbohydrate intake than A allele carriers (p=0.026). These findings suggest that while cd36 rs1761667 may not be a primary determinant of fat taste sensitivity in this cohort, it may contribute modestly to body fat composition and dietary behaviors through interactions with gender and BMI status.

Downloads

Download data is not yet available.

References

World Health Organization. World Health Statistics 2024: Monitoring Health for the SDGs, Sustainable Development Goals. Geneva: World Health Organization; 2024.

Schorr M, Dichtel LE, Gerweck AV, Valera RD, Torriani M, Miller KK, Bredella MA. Sex Differences in Body Composition and Association With Cardiometabolic Risk. Biology of Sex Differences. 2018 Apr;9(28):1–10.

Survei Kesehatan Indonesia (SKI). Laporan Survei Kesehatan Indonesia 2023. Jakarta: Kementerian Kesehatan Badan Kebijakan dan Pembangunan Kesehatan; 2023.

World Health Organization. The Asia-Pacific Perspective: Redefining Obesity and Its Treatment. Sydney: Health Communications Australia; 2000.

Ozturk EE, Dikmen D. Association Between Fat Taste Sensitivity and Diet Quality in Healthy Male Turkish Adults. Food Science and Technology (Campinas). 2022 Jan;42(1):1–8.

Wang L, Wang H, Zhang B, Popkin BM. Elevated Fat Intake Increases Body Weight and the Risk of Overweight and Obesity Among Chinese Adults: 1991–2015 Trends. Nutrients. 2020 Nov;12(3272):1–13.

Suzanne AA, Winaktu GJMT, Fabiani H, Susanto LB. Perubahan Sensitivitas Indera Perasa pada Anak Dengan Obesitas. J MedScientiae. 2022 Oct;1(2):54–61.

Asano M, Hong G, Matsuyama Y, Wang W, Izumi S, Izumi M, Toda T, Kudo TA. Association of Oral Fat Sensitivity With Body Mass Index, Taste Preference, and Eating Habits in Healthy Japanese Young Adults. The Tohoku Journal of Experimental Medicine. 2016 Feb;238(2):93–103.

Mattes RD. Oral Threshold and Suprathreshold Intensity Ratings for Free Fatty Acids on Three Tongue Sites in Humans: Implications for Transduction Mechanisms. Chemical Senses. 2009 Jun;34(5):415–23.

Costanzo A, Orellana L, Nowson C, Duesing K, Keast R. Fat Taste Sensitivity Is Associated With Short-Term and Habitual Fat Intake. Nutrients. 2017 Aug;9(781):1–12.

Mrizak I, Šerý O, Plesnik J, Arfa A, Fekih M, Bouslema A, Zaouali M, Tabka Z, Khan NA. The A Allele of Cluster of Differentiation 36 (CD36) SNP 1761667 Associates With Decreased Lipid Taste Perception in Obese Tunisian Women. British Journal of Nutrition. 2015 Apr;113(8):1330–7.

Pepino MY, Gregory LL, Klein S, Abumrad NA. The Fatty Acid Translocase Gene CD36 and Lingual Lipase Influence Oral Sensitivity to Fat in Obese Subjects. Journal of Lipid Research. 2012 Mar;53(3):561–6.

Bahauddin AR, Karim R, Saari N, Mohd Shariff Z. Association Between CD36 Gene Variants, PROP Taster Status and Oral Fatty Taste Intensity Perception Among Malaysian Obese and Non-Obese Subjects. International Food Research Journal. 2018 Jan;25(1):29–42.

Duarte MKRN, Leite-Lais L, Agnez-Lima LF, Maciel BLL, Morais AHA. Obesity and Nutrigenetics Testing: New Insights. Nutrients. 2024 May;16(5):1–16.

Wright MH, Adelskov J, Greene AC. Bacterial DNA Extraction Using Individual Enzymes and Phenol/Chloroform Separation. Journal of Microbiology and Biology Education. 2017 Aug;18(2):1–3.

Fujii R, Hishida A, Suzuki K, Imaeda N, Goto C, Hamajima N, Wakai K, Kondo T. Cluster of Differentiation 36 Gene Polymorphism (rs1761667) Is Associated With Dietary MUFA Intake and Hypertension in a Japanese Population. British Journal of Nutrition. 2019 Jun;121(11):1215–22.

Haryono RY, Sprajcer M, Keast R. Measuring Oral Fatty Acid Thresholds, Fat Perception, Fatty Food Liking, and Papillae Density in Humans. Journal of Visualized Experiments. 2014 Jul;88(1):1–12.

Chandrasheparappa SM, Puttannaiah SM, Mohandas A. Comparison of 24 h Recall and 3-Day Dietary Cycle With 7-Day Dietary Cycle as a Tool for Dietary Assessment at Community Level in Rural South Indian Community: A Cross-Sectional Study. International Journal of Medical Science and Public Health. 2019 Feb;9(2):174–8.

Keller KL, Liang LC, Sakimura J, May D, van Belle C, Breen C, Driggin E, Tepper BJ, Lanzano PC, Deng L, Chung WK. Common Variants in the CD36 Gene Are Associated With Oral Fat Perception, Fat Preferences, and Obesity in African Americans. Obesity. 2012 May;20(5):1066–73.

Salim S, Kartawidjajaputra F, Suwanto A. Association of FTO rs9939609 and CD36 rs1761667 With Visceral Obesity. Journal of Nutritional Science and Vitaminology. 2020 Aug;66:329–35.

Melis M, Sollai G, Muroni P, Crnjar R, Barbarossa IT. Associations Between Orosensory Perception of Oleic Acid, the Common Single Nucleotide Polymorphisms (rs1761667 and rs1527483) in the CD36 Gene, and 6-n-Propylthiouracil (PROP) Tasting. Nutrients. 2015 Jan 1;7(1):2068–84.

Tucker RM, Nuessle TM, Garneau NL, Smutzer G, Mattes RD. No Difference in Perceived Intensity of Linoleic Acid in the Oral Cavity Between Obese and Nonobese Individuals. Chemical Senses. 2015 Oct;40(8):557–63.

Stewart JE, Newman LR, Keast RSJ. Oral Sensitivity to Oleic Acid Is Associated With Fat Intake and Body Mass Index. Clinical Nutrition. 2011 Dec;30(6):838–44.

Ramos-Lopez O, Panduro A, Martinez-Lopez E, Fierro NA, Ojeda-Granados C, Sepulveda-Villegas M, Roman S. Genetic Variant in the CD36 Gene (rs1761667) Is Associated With Higher Fat Intake and High Serum Cholesterol Among the Population of West Mexico. Journal of Nutrition and Food Sciences. 2015 Apr;5(2):1–5.

Melis M, Carta G, Pintus S, Pintus P, Piras CA, Murru E, Manca C, Marzo VD, Banni S, Barbarossa IT. Polymorphism rs1761667 in the CD36 Gene Is Associated to Changes in Fatty Acid Metabolism and Circulating Endocannabinoid Levels Distinctively in Normal Weight and Obese Subjects. Frontiers in Physiology. 2017 Oct 21;8:1006

Kementerian Kesehatan RI. Permenkes RI No. 75 Tahun 2013 Tentang Angka Kecukupan Gizi yang Dianjurkan Bagi Bangsa Indonesia. Jakarta: Kementerian Kesehatan Republik Indonesia; 2013.

Ong HH, Tan YN, Say YH. Fatty Acid Translocase Gene CD36 rs1527483 Variant Influences Oral Fat Perception in Malaysian Subjects. Physiology and Behavior. 2017 Jan;168:128–37.