The Anticancer Activity of Ethanol Extract of Begonia medicinalis on Colorectal Cancer Rat Model Induced With 7,12-Dimethylbenz[A]Anthracene

Musjaya Guli; Muh Akbar Ardiputra; Ramadanil Pitopang; Retno Sari; Mochammad Hatta; Sumarno Reto Prawiro; Andi Saifah; Bambang Sardi; Rahma Rahma; Nurul Dina Rahmawati

doi:10.56303/jhnresearch.v4i2.411

Authors

Musjaya Guli Department of Biology, Tadulako University, Palu, Indonesia
Muh Akbar Ardiputra Department of Biology, Tadulako University, Palu, Indonesia https://orcid.org/0009-0007-7244-6115
Ramadanil Pitopang Department of Biology, Tadulako University, Palu, Indonesia
Retno Sari Department of Biology, Tadulako University, Palu, Indonesia
Mochammad Hatta Department of Molecular Biology and Immunology, Hasanuddin University, Makassar, Indonesia
Sumarno Reto Prawiro Department of Clinical Microbiology, Brawijaya University, Malang, Indonesia
Andi Saifah Department of Nursing, Tadulako University, Palu, Indonesia
Bambang Sardi Research Center for Advanced Materials, National Research and Innovation Agency, South Tangerang, Indonesia
Rahma Rahma Master’s Program of Biomedical Science, Indonesia University, Jakarta, Indonesia
Nurul Dina Rahmawati Department of Nutrition, Indonesia University, Depok, Indonesia

Keywords:

Begonia medicinalis, Colorectal Cancer, Ethnopharmacology, Neutrophil, 7,12-dimethylbenz[a]anthracene

Abstract

Colorectal cancer remains one of the leading causes of cancer-related deaths after lung cancer, highlighting the urgent need for more effective therapies with minimal side effects. Begonia medicinalis has been reported to have potential anticancer properties. This study aimed to evaluate the anticancer activity of Begonia medicinalis extract by assessing neutrophil concentration in a 7,12-dimethylbenz[a]anthracene (DMBA)-induced colorectal cancer rat model. The research employed a laboratory-based experimental approach with a post-test-only group design, comprising five groups with five replications each: treatment group I receiving a 25 mg/kg body weight, treatment group II receiving a 50 mg/kg body weight, treatment group III receiving a 100 mg/kg body weight, an normal group that was not DMBA-induced and did not receive therapy, and a negative control group that was DMBA-induced but did not receive therapy. The results of this study demonstrate that Begonia medicinalis extract effectively suppresses neutrophil concentration in a DMBA-induced colorectal cancer rat model. Treatment with 50 mg/kg body weight and 100 mg/kg body weight doses successfully reduced neutrophil cell levels in the experimental subjects, with the best results seen at the 100 mg/kg body weight dosage. This study provides new insights into the effects of plant-based therapies, Begonia medicinalis extract, in modulating the immune system by suppressing neutrophil concentration in a colorectal cancer rat model.

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